Wound Healing in Rats Intraperitoneally Treated with Sea Cucumber Stichopus vastus (Glycosaminoglycans)

Marine creature such as sea cucumbers are rich in glycosaminoglycans (GAGs). It is famous and has long been utilised traditional remedies commonly used wound healing therapy. This study designed to explore the effect of GAGs cucumber especially from integument wall Stichopus vastus for by intra-peritoneally injected rats daily.
 
 Complete randomised design was this where a total twenty male Sprague-dawley were divided 4 groups; 3 treatment groups (2 mg/kg, mg/kg 6 mg/kg) one control group phosphate buffer saline (PBS) with sample size n=6 per group. Rats weight 250 400 grams treated daily 12 days. An excisional created using biopsy punch diameter mm. Treatment S. part left opened without topically applied antiseptic prevent bias 12th days’ period evaluation.
 Result obtained measuring (mm) ruler or caliper (Figure 1) recorded on day 1, followed calculation contraction percentage. The percentage evaluation found out that compound shows no significant difference between all 12. However, treatment, 2 higher compared other groups. extraction can speed up which enhance promote closure.
 reliable parameters evaluate process later leads closure; healed [1]. Wound be defined shrinkage open normal skin moves centrally site at end give small scar [2]. From previous study, fish showed an accelerating had discovered have good potential antimicrobial activity. abilities fight against microbial mainly aureaus extend anti-inflammatory phase instance early [3]. Besides, Pereira et al. (2019) [4] that, Calendula officinalis (marigold); containing [5], topical rats’ enhancing acute it increased epithelialisation, contraction, collagen formation new vessel formation. Thus, hypothesised extract strong speeding healing.